Mesembrine comes from Sceletium tortuosum, a succulent native to South Africa. Historical records describe its use by the San and Khoi people for mood elevation, tension relief, and stamina during demanding tasks. Modern extraction methods standardise key alkaloids — including mesembrine, mesembrenone, and mesembrenol — for consistent effects.

• Timing: 30–45 minutes before training, or on high-stress days when you need composure.
• Typical range: Many formulas land around 30–100 mg of mesembrine-containing extract per serve. Start low; assess response.
• Stacks: Works well with electrolytes, taurine, and citrulline for performance, or as a standalone for mood support.

Always follow the label for your specific product and speak with your healthcare professional if you have medical conditions or take prescription medicines.

• General tolerance: Usually well tolerated at recommended amounts; occasional mild nausea or headache may occur.
• Medication interactions: Because mesembrine can affect serotonin signalling, do not combine with SSRIs, SNRIs, MAOIs, or other serotonergic agents without medical guidance.
• Pregnancy/breastfeeding: Insufficient data — seek professional advice.
• Legal status: Varies by region. Always check local regulations and purchase from reputable sources.

• Smith MT et al. Psychoactive constituents of Sceletium — J Ethnopharmacol (1996).
• Patnala S & Kanfer I. Kougoed fermentation & phytochemicals — J Ethnopharmacol (2009).
• Terburg D et al. Acute effects of Sceletium tortuosum (PDE4 & 5-HT) — Neuropsychopharmacology (2013).
• Nell H et al. Randomised trial of Sceletium extract — J Alt Complement Med (2013).
• Chiu S et al. PDE4-targeted extract & cognition — EBCAM (2014).
• Gericke N & Viljoen AM. Sceletium review update — J Ethnopharmacol (2008).
• Coetzee DD et al. High-mesembrine extract mechanisms — J Ethnopharmacol (2016).

Educational content only — not medical advice.